This invention discloses a phosphocreatine disodium salt six-hydrate and its preparation method. The compound is phosphocreatine disodium salt with high purity and six-crystal water, and the preparation method includes the following steps: (1) Kondens of creatinine and phosphorus oxychloride prepares creatinine phosphorus oxychloride, (2) creatinine phosphorus oxychloride is taken the ring opening reaction to get crude phosphorus disodium, (3) purification and crystallization gets the target product. This invention has the advantages of high purity suitable for the manufacture of injection powder, and it avoids the large use of solvents with high yield of products. The excessive phosphorus oxychloride is reused with distillation, and the product has high purity through intermediate and resin purification. It has no potential safety problem about heavy metal residues, and can effectively improve the clarification to reach the intravenous requirement. |