Human tumor necrosin relative death inducing ligand mutein and its prepn process and medicine composition

Original document(13 pages) Authorized document(13 pages) 中文版

The present invention discloses a human tumor necrosion relative death inducing ligand mutein with Ser52Asn and Trp82Gln mutation, the mutein encoding DNA sequence, expression vector containing the DNA sequence, host cell transformed by the expression vector, medicine composition containing the mutein, and the preparation process of the mutein. The mutein has affinity greatly higher than natural protein and has somewhat higher expression amountin host cell.

Application Number 申请号	01132158	Application Date 申请日	2001.11.09
Title 名称	Human tumor necrosin relative death inducing ligand mutein and its prepn process and medicine composition
Publication Number 公开号	1417229	Publication Date 公开日	2003.05.14
Approval Pub. Date		Granted Pub. Date	2005.01.12
International Classification 分类号	A61K38/17,A61P35/00,C07H21/04,C07K14/435,C12N15/12,C12N15/63,C12N15/64
Applicant(s) Name 申请人	Zhongxin Guojian Pharmaceutical Industry Co., Ltd., Shanghai
Address 地址	200120
Inventor(s) Name 发明人	Hu Hui
Attorney & Agent 代理人	xu xun

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