The invention relates to a method to make enzymolysis or microbe fermentation hydrolyzation on ginsenoside to prepare three hydroxyl dissociative low-polarity ginsenosides: 20-O-beta-D-xylopyranosyl (1->6)-beta-D-glucopyranosyl-20(s)- protopanaxadiol, called Mx for short, 20-O-alpha-L- arabinopyranosyl (1->6)-beta-D-glucopyranosyl- 20(s)-protopanaxadiol, called C-Y for short, and 20-O-alpha-L- arabinofuranosyl (1->6)-beta-D-glucopyranosyl-20(s)- protopanaxadiol, called Mc for short, especially a coarse snail enzymatic hydrolysis preparing method. The technique is simple, the cost is low and the recovery is high. |